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Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA, Cell Res, 9 Sep 2020

发布时间:2020年09月08日

Cell Research优盈平台注册, 9 September, 2020, DOI:

Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA

Hui Chen, Yang Cui, Xuling Han, Wei Hu, Min Sun, Yong Zhang, Pei-Hui Wang, Guangtao Song, Wei Chen & Jizhong Lou

Abstract

优盈平台注册The COVID-19 pandemic worldwide is caused by a novel coronavirus SARS-CoV-2 (the severe acute respiratory syndrome coronavirus 2). After viral invasion into the host cells, the ~30?kb viral genome RNA injected is translated into structural and non-structural proteins to replicate viral genome and assemble more viral particles. Many copies of nucleocapsid (N) protein can bind to viral genome RNA and pack it into ~100?nm particles, assisting membrane (M) and envelope (E) proteins to efficiently assemble the viral envelope. The exact molecular mechanism by which N protein packs up the viral genome still remains elusive.

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